Diagnostic and therapeutic potential of transforming growth factor beta 1 in solid organ transplantation: recent research findings

Federation Clinical outcomes of solid organ transplantation depend on many factors. One the main factors is risk post-transplant complications, which affect allograft and recipient survival. Multifactorial damage in complications search for diagnostic prognostic indicators condition have contributed to study selection a wide range proteomic molecular genetic biomarkers, shown be effective transplantation. The use biomarkers opens up additional possibilities assessing their early diagnosis. This potentially reduces frequency invasive procedures. Transforming growth factor beta 1 (TGF-β1) regulates biological processes, has anti-inflammatory immunosuppressive effects, participates immune response, plays key role extracellular matrix (ECM) protein synthesis. ECM dysregulation leads fibroblast hyperproliferation increased collagen synthesis and, consequently, tissue fibrosis. variability potential TGF-β1 been demonstrated studies recipients various organs. objective this review analyze recent evidence development assess its prospects as marker graft pathology or target therapy.